EGCG – More Than Just Antioxidant

EGCG – More Than Just Antioxidant

Tea is the second most consumed beverage in the world and its beneficial properties have been widely explored. Green tea has been used in folk remedy for centuries. Tea leaf is rich in polyphenols and flavonoids. The flavonoid EGCG (epigallocatechin gallate) is considered the main active and important ingredient of green tea. Over the past few decades, EGCG has been suggested to have beneficial antioxidant activities. These activities are necessary for scavenging free radicals that impair cell function. One of significance of antioxidant profile of EGCG is to prevent cigarette smoking stress oxidative.

Cigarette smoking is a complex mixture of over 4800 constituents including high concentration of free radicals. These free radicals contained in cigarette have been established as major risk factor for cardiovascular events such as coronary obstruction, acute myocardial infarction and increased risk of atherogenesis. Potential mechanisms of free radicals exerting these events has been proposed, including endothelial dysfunction, oxidative stress, and increased circulatory inflammatory mediators. As these event s are harmful for our health, there is need for strong and safe antioxidant.

EGCG as natural antioxidant from tea leaf has been proved to ameliorate oxidative stress in cigarette-smoking related disease. EGCG has been studied and it indicates vascular protective, anti inflammatory and anti oxidative profile in cardiovascular system in cigarette smoking-induced rats. Group of rats that is given oral pretreatment with EGCG showed significant decrease in the levels of pro oxidant and improved antioxidant status. This study shows EGCG has advantage in preventing and repairing stress oxidative caused by cigarette smoking.

EGCG has also been reported improving glucose tolerance. Researchers show that EGCG supports glucose metabolism by preventing sudden increase of blood glucose. This result is shown by research that the group of mice given EGCG after meal has lower increase of blood glucose compared to group that is not given EGCG. EGCG has also activity to improve the function of pancreatic β cell. It was previously shown that EGCG ameliorate β cell damage in group of diabetic mice induced by streptozotocin (STZ). In the trial, the group of mice given EGCG has lower incidence of β cell damage. This present study provides evidence that EGCG has beneficial properties in blood glucose control.

For its beneficial effects, EGCG should be considered as dietary supplementation to provide great antioxidant activities to scavenge free radicals. VIPRO G, with EGCG as the main ingredient provides antioxidant profile for daily need. VIPRO G also contains Taurine and Vitamin C, the two ingredients known for its effect to prevent and restore endothelial dysfunction. Zinc picolinate in VIPRO G also plays role in supporting immune system for better health.

As conclusion, VIPRO G containing EGCG, Taurine and Vitamin C fulfills the need of strong and safe antioxidant to scavenge free radicals and improve general health.

Source:

  1. Ortsater, H., Grankvist, N., Wolfram, S., Kuehn, N., Sjoholm, A.; Diet Supplementation with Green Tea Extract : Epigallocatechin Gallate Prevents Progression to Glucose Intolerance in Mice; Nutrition & Metabolism : Bio Med Central; 2012, 9:11.
  2. Tsuneki, H., et.al., Effect of Green Tea on Blood Glucose Levels and Serum Proteomic Patterns in Diabetic Mice and on Glucose Metabolism in Healthy Humans. BMC Pharmacology : 2004, 4:18.
  3. Gokulakrisnan, A.,Vinayagam, M.M.,Abdul Rahman, L.A., Thirunavukkarasu, C., Attenuation of Cardiac Oxidative Stress by EGCG in Cigarette Smoking-Exposed Rats. Biomedicine and Pharmacology. Elsevier Masson. 2010.

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