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Usually we meet someone both man and adult woman who have an unattractive appearance from the calf to the legs, blood vessels (veins) are seen protruding out in blue or purple. Sometimes it resembles a knot or a twisted cord. It occurs because of the valve in the vein is inhibited or it is at a prolonged edge pressure so that the valve could be dilated and causing impaired blood flow. This condition is known as varicose veins. According to the American Heart Association, the prevalence of varicose veins is about 5-30% of the adult population and is more common in women than in men (3: 1).

Varicose veins are swelling and / or dilation of veins which usually occurs on the legs because of the build-up of blood as a result of standing and or sitting for too long as well as potentially becoming a chronic disease with terms Chronic Venous Insufficiency (CVI). Moreover, other symptoms that can accompany varicose veins are swelling of the lower leg (including the ankle), feet feeling heavy and uncomfortable, discoloration of the lower leg skin or dry-looking skin, and leg muscle cramps.

CVI has several stadiums according to CEAP standards (Clinical, Etiologic, Anatomy, Pathology) with different handling. The clinical stage CVI according to CEAP classification is:

• C0 : no signs of visible or palpable venous disease

• C1 : telangiectasia or reticular veins

• C2 : varicose veins (differentiated from reticular veins with> 3 mm in diameter)

• C3 : oedema

• C4 : changes in the secondary skin to chronic venous disease

- C4a : pigmentation or exim

- C4b : lipodermatosklerosis or atrophieblanche

• C5 : venous ulcer healed

• C6 : active venous ulcers

There are several efforts that can be done to eliminate varicose veins:

  1. Reduce weight to the ideal weight if proven to be overweight
  2. Avoid standing for too long
  3. Do moderate-to-moderate intensity exercise regularly
  4. Use special stockings for varicose veins (compression stocking)
  5. Medical therapy, selection by considering the location, number and severity of varicose veins:    

a.drugs, can generally be useful in mild varicose veins, such as drugs containing diosmin-hesperidin

b. injection of sclerotherapy


dradiofrequency / ablation


amvar-thumbPT. Simex Pharmaceutical Indonesia comes with AMVAR containing Citrus bioflavonoid micronization (Combination Diosmin 450 mg and Hesperidin 50 mg). Diosmin-Hesperidin widely used as a natural and effective supplement for over 30 years in many countries as a haemorrhoids treatment, lymphedema, Chronic Venous Insufficiency, and varicose veins.

Based on journals related to the effectiveness of diosmin-hesperidin, AMVAR consumption for 2 to 3 weeks can help reduce varicose veins by helping to improve the dilation of blood vessels / edge pressure of the blood vessel wall (elasticity) in the legs. This drug is also recommended for people who do not have varicose veins, but has a high risk for varicose veins, because of being overweight or have a job that can put pressure on the blood vessels for too long standing or sitting.

AMVAR suitable for both man and woman consumption and safe for consumption in the long time, a box AMVAR contain 5 strip @ 6 coated caplet. For cases of varicose veins and symptoms due to varicose veins can consume 4 – 6 caplet per day during the first week continued use for the maintenance can consume 2 caplets per day for approximately 2 weeks, and during consuming AMVAR it is also recommended to do a healthy lifestyle to avoid the risk factors for varicose veins.








1.Douglas MacKay, ND Candidate. Hemorrhoids and Varicose Veins: A Review of Treatment Options.Portland.Thorne



5.Product Profile Amvar.2018.Jakarta: PT.Simex Pharmaceutical Indonesia

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