The elderly period is the final stage of adulthood for everyone. This stage usually begins at 60 years old and is characterized by the number of lifestyle changes from the physical, cognitive and psychosocial. Among them, physical change is the most significant change felt. Significant physical changes make these elderly need the most of health services aimed to prevent the occurrence of emergency cases. Physical changes occur in all physical organs such as reduced body organ function, reduced body defense capacity, unbalanced hormone levels in the body especially and others.
Significant physical changes will cause various diseases to infect elderly from minor to severe illness and make some complications. Among various infectious diseases of elderly human, osteoarthritis is one of the well-known illnesses. Osteoarthritis is a degenerative joint disease that affects joint cartilage. Osteoarthritis occurs due to damage to the cartilage that protects and provides a cushion for the joint that causes pain and stiffness. In addition, lack of join fluid called synovial fluid is also considered as one of the trigger factors. As a result this disease becomes one of the diseases that can cause disability.
Osteoarthritis is caused by various factors including genetic factors, sex especially in menopausal women caused by hormonal body, history of trauma, age, and obesity. Symptoms of osteoarthritis occur gradually. Symptoms begin with the onset of stiffness especially after heavy activity and then become more severe depend on the time, appear of spot red, loss of joint flexibility, and appear pain in the joint.
Osteoarthritis is known as a disease that occurs in the long period, so this illness doesn’t have specific treatment. There are several aimed of osteoarthritis treatment such as to reduce of pain caused by osteoarthritis, to maintain function of joints so that it can perform activities, to prevent the occurrence of deformity, to prevent the occurrence of repeated attacks and also to reduce the side effects caused by drug use especially the analegtic drugs, use of pain treatment. The use of pain treatment is the first thing to do base on the management of osteoarthritis therapy. To resolve of pain, use of NSAIDs (Non steroidal Anti-inflammatory Drugs) is the main choice. However, from clinical studies, long-term use of NSAIDs can cause a variety of indigestion problems such as nausea, vomiting, dyspepsia and others.
The use of supplements is a matter of concern since early because dietary supplements usually contain safer components and more minimal side effects. Various natural ingredients have been used as a supplement especially for osteoarthritis therapy. One of them is a combination of glucosamine and chondroitin. This combination is known as a combination of appropriate and effective supplements because of its synergistic effectiveness.
Glucosamine is an important sugar compound in various biochemical syntheses. Based on functionalities in the joint, glucosamine is a compound that can improve cartilage. The mechanism is by stimulating cartilage cells for the formation of proteoglycans and collagen which are essential proteins of articular cartilage. Appropriate dose for use in Osteoarthritis therapy is 500 – 1500 mg per day.
Chondroitin or chondroitin sulfate is a sulphatized glycosaminoglycan composed of a branched chain of sugar. This compound is part of the proteoglycans so that this component is an important component of cartilage network and plays a role in increasing resistance to pressure. In addition, chondroitin is also known as anti-inflammatory through blocking enzymes that can break down cartilage. The recommended effective dose for osteoarthritis therapy is 800 to 1200 mg per day.
Based on that, PT SIMEX PHARMACEUTICAL INDONESIA as one of the pharmaceutical companies in Indonesia presents Good Life GCM as a supplement of choice to resolve the problem of osteoarthritis therapy. Good Life GCM is a right combination between Glucosamine, Chondroitin and Methylsulfonate Methane (MSM). MSM is a sulfur-containing compound that is necessary for the tendons and muscles and also can reduce pain and swelling in osteoarthritis patients. The mechanism works by helping to increase the cortisol hormone. In addition MSM also serves as an antioxidant that can suppress the activity of free radicals in the body.
Good Life GCM products are available in two dosage forms, sachet and caplet form. The sachet form is known as Good Life GCM Forte and the caplet form is known as Good Life GCM. Good Life GCM FORTE containing 1500 mg of glucosamine, 1200 mg of chondroitin and 500 mg of MSM which consumed once daily by dissolving in warm water. Good LifeGCM KAPLET products containing 500mg of glucosamine, 400 mg of chondroitin and 200 mg of MSM, drink consumption with dose frequency 3 times of 1 caplet for a day.
In conclusion, Good Life GCM containing glucosamine, chondroitin and MSM and equipped with various minerals, is the right choice to help repairing joint and cartilage damage and is able to help reduce pain due to joint inflammation of osteoarthritis.
- Teslim O., et al. 2014. Side effects of non-steroidal anti-inflammatory drugs: The experience of patients with musculoskeletal. American Journal of Health Research. Vol 2 (4): 106-112.
- Sinusas K., 2012. Osteoarthritis: Diagnosis and Treatment. The American Family Physician. Vol. 85 (1): 49-56.
- Roman J., Casaneda S., et al. 2017. Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impairment in Patients With Knee Osteoarthritis. Vol 69 (1): 77-85.