Protective Therapy For Liver

Liver

Hepatitis and Liver Problems

Liver is the largest and the most important metabolic organ in our body. It has several function affecting other organs function, such as metabolism in our body. Impaired metabolism in liver will disrupt entire blood function resulting in impaired distribution of nutrients throughout our body.
As metabolic organ, liver may experience inflammatory reaction, so called hepatitis. Cause of hepatitis can be classified to infection and non infection. Infection cause of hepatitis usually occurs due to viral infection, resulting in hepatitis A, B, C, D, E, or F. Non infection cause of hepatitis may include alcohol and drugs that impair liver metabolism. Hepatitis has become one of top ten cause of death worldwide. Indonesia is ranked in third place after India and China for the total number of patients suffering hepatitis.
Liver is a well-regenerating organ and able to recover from tissue or cell damage. The regeneration ability of liver cells is excellent, as example is in patients undergoing liver transplantation, liver cells recover in approximately 3 times 24 hours. However, if liver cells are continuously damaged (i.e experiencing repeated inflammation), they will form connective tissue that will disrupt structure of liver tissue, resulting in disorder of liver function. The connective tissue will induce stiffness in liver tissue, resulting a condition called cirrhosis of liver. Cirrhosis of liver will end in liver failure once the cirrhotic part occurs in most of liver tissue.
As detection of damage, liver itself secrete some enzymes which can be examined through laboratory examination. Essential enzymes known as liver function test indicator are Aspartate Transaminase (AST) or Serum Glutamic Oxaloacetic Transaminase (SGOT), Alanin Transaminase (ALT) or Serum Glutamic Pyruvic Transaminase (SGPT) and Gamma Glutamate Transferase (GGT). These enzymes are mostly secreted abundantly in state of liver inflammation in which the level of these enzymes may multiplicate to hundred times.
Detection of liver damage can be performed by gathering information about patient’s sign and symptom. Signs and symptoms of liver damage may vary, from mild, moderate to severe signs and symptoms. Signs and symptoms that usually occur in patients suffering liver damage are nausea, vomiting, change in skin color (i.e yellowish color of skin), loss of appetite, fatigue, rapid weight loss, liver enlargement, swelling, abnormal venous enlargement in abdominal wall and other signs or symptoms. These signs and symptoms should be warning for early treatment since further delay of treatment will result in worse condition. Physical and laboratory examination should be performed simultaneously for early detection of liver damage. As mentioned before, liver is equipped with excellent ability to recover, making liver able to sustain to perform its function even if there is mild damage. Obvious disruption of liver function will occur once there is approximately 80 % of liver tissue is damaged. Therefore, it will bring most benefit if we support liver health by adding hepatoprotector in early stage of liver damage to prevent worsening condition of liver damage.

Curcuminoid and Sylimarine as Hepatoprotectors

Hepatoprotector is term for groups of chemical substances that perform protection to liver tissue and enhance recovery in damaged-liver tissue. Curcuminoid and Sylimarine are natural and well-known ingredients for their hepatoprotective mechanisms. These substances protect and recover liver tissue from hepatotoxic agents such as alcohol, drugs, metal particles, pollutants and pesticides.
Curcuminoid is natural substance derived from curcuma plant (Curcuma xanthorhiza). It has been used worldwide as natural medicine since early of 18th century. It performs anti oxidant and anti inflammatory function to cells, especially liver cells. In a study performed in male Wistar rats using carbon tetrachloride (CCl4) as hepatotoxic agents shows that group using curcumin is capable to prevent liver injury. It is suggested that curcumin prevents acute liver damage by acting as antioxidant and supressing inflammatory mediators. Another clinical trial performed in Indonesia involving 38 patients with liver disorder and SGOT and SGPT levels above normal range shows that based on statistical result, after 14 days of therapy using curcumin level of SGOT may decrease up to 2,89 times and SGPT level may decrease up to 3,28 times than before therapy. For hepatitis patients, level of SGOT may decrease up to 3,48 times and level of SGPT may decrease to 3,82 times than before therapy.
Other substance well-known for its hepatoprotective mechanism is sylimarine. Sylimarine is chemical substance containing mixture of flavonoids such as Sylibin, Sylidianin and Sylichristin. These substances are derived from plant named Sylibum marianum, also called “milk thistle”. Sylimarine has been used since medieval times to treat liver disease for it performs antioxidant profile and promotes regeneration of liver cells. Sylimarine is also capable to block toxins entering liver cells by inhibiting absorption of harmful substance to liver cells. In a randomized, placebo-controlled trial involving more than 20 patients with chronic hepatitis, group consuming sylimarine for one week shows decrease in SGOT, SGPT and GGT significantly. Another study also shows similar result in which sylimarine given for 8 weeks in 2637 patients with chronic hepatitis. The study shows that subjective complaints improve up to 63%, level of SGOT decrease up to 36 %, level of SGPT decrease up to 34% and level of GGT decrease up to 46%.
pro-liver-thumb

PROLIVER as Hepatoprotector

Good Life Proliver from Simex Pharmaceutical Indonesia is an excellent hepatoprotector product, containing curcuminoid and sylimarine as main content to prevent liver cells damage and promote regeneration in liver cells. Aside from curcuminoid and sylimarine, Good Life Proliver also contains choline bitartrate and vitamin B6 to reduce lipid accumulation in liver tissue and improve liver metabolism. With great combination of natural products, Good Life Proliver is the right choice as protective therapy for liver.

Source :

  1. Mayer KE, Myers RP, Lee SS. Silymarin treatment of viral hepatitis. Journal of Viral Hepatitis.2005;12:559-567.
  2. Flora K, Hahn M, Rosen H. Milkthiste (Silybum marianum) for the therapy of liver disease.Am J Gastroentero.2009; 93:139-143.
  3. Reyes-Gordillo, José Segovia, Mineko Shibayama, Paula Vergara, Mario G. Moreno, Pablo Muriel. Curcumin protect against acute liver damage in rat by inhibiting NF-κB, proinflammatory cytokines production and oxidative stress. Biochimica et Biophysica Acta Vol 1770 . 2007; 989–996
  4. www.helmigs.com/healtharticles.php?lang=id
  5. www.lizaherbal.com/main/index2.php?option=com_content&do_pdf=1&id=182

16 Responses to “Protective Therapy For Liver”

  1. Barbra

    Thank you for any other informative web site.
    Where else may I get that kind of info written in such a perfect method?

    I have a project that I am just now working on, and I have been on
    the look out for such information.

    Reply
    • PT. Simex Pharmaceutical Indonesia

      Dear Barbra,

      Thank you for your question.
      For further information about our products or other articles please check our website regularly for we submit our articles periodically. We also look forward for any suggestion for topics of our articles.

      Regards,
      PT Simex Pharmaceutical Indonesia

      Reply
  2. google plus android

    I have been surfing online more than 4 hours today, yet
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    Reply
    • PT. Simex Pharmaceutical Indonesia

      Hello Darlene,

      It’s nice to give informative articles regarding health and supplementation for health. We’re glad that you like our website and our published articles. Please look forward for upcoming articles about omega 3 and cholesterol. We sincerely hope that this article useful for anyone especially health-concerned people.

      Regards,
      PT Simex Pharmaceutical Indonesia

      Reply
  3. samsudin

    saya makan proliver ketika saya terdeteksi hepatitis A dengan sgot sgpt tinggi….ternyata terbukti ampuh…terima kasih proliver

    Reply
    • PT. Simex Pharmaceutical Indonesia

      Dear Pak Samsudin,

      Terimakasih atas kepercayaan Bapak terhadap produk kami. Kami akan tetap berusaha mengembangkan produk-produk berkualitas.
      Semoga produk kami tetap menjadi produk pilihan Bapak dalam menjaga kesehatan.

      Regards,
      PT.Simex Pharmaceutical Indonesia

      Reply
  4. Bukari Sodimedjo, 72 th, pensiunan TNI-AD (Letan Kolonel CKM purn)

    Tanggal 22-9-2014 saya membeli TABLET PRO LIVER 30 bj (resep dokter), sekitar 40 – 50 % kalau dibuka dari bungkusnya tabletnya BELAH. Tanda pembuatan tidak tercantum, hanya ada POM SD. 091.536.071, Simex, Good Life. Kenapa demikian, kurang baikkah massa tabletnya atau campurannya ? Terima kasih. (Saya pernah bekerja di pabrik obat dan gudang obat selama 13 th dan bekerja di rumah sakit selama 14 th).

    Reply
    • PT. Simex Pharmaceutical Indonesia

      Kepada Yth Letnan Kolonel CKM Purn Bapak Bukari Sodimedjo,

      Terima kasih untuk surat bapak kepada kami. Menanggapi pertanyaan bapak mengenai tablet Proliver kami yang ternyata sudah terbelah dari dalam bungkusnya, berikut penjelasan yang dapat kami berikan :
      1. Tablet Proliver mengandung bahan aktif Curcuminoid yaitu senyawa kurkumin yang bersifat higroskopis sehingga mudah menarik air. Curcuminoid ini jika terkena uap air atau berada dalam ruangan atau keadaan dengan kelembaban tinggi akan mudah menarik uap air sehingga lambat laun tablet ataupun kaplet yang mengandung curcuminoid akan menggembung dan akhirnya menimbulkan keretakan di kaplet.
      2. Untuk massa tablet atau campuran dari Proliver, kami telah melakukan test untuk mencari tahu penyebab keretakannya dan ditemukan bahwa penyebabnya adalah adanya sifat higroskopis dari curcuminoid ini. Uji toksisitas juga telah kami lakukan dan hasilnya tidak ditemukan bahan toksik yang menyebabkan keretakan kaplet Proliver. Diperkirakan pada saat produksi di pabrik, pengiriman ataupun penyimpanan di distributor ataupun apotek mungkin mengalami kelembaban sehingga kaplet Proliver mengalami keretakan. Kami telah memperbaiki sistem produksi serta pengiriman dan penyimpanan Proliver sehingga ke depannya produk Proliver tidak lagi mengalami kerusakan.

      Demikian penjelasan yang dapat kami berikan. Besar harapan kami agar bapak tetap dapat mempercayai produk Proliver dari PT. Simex Pharmaceutical. Jika bapak mengalami keluhan yang sama dari kaplet Proliver atau produk lain kami di waktu mendatang, bapak dapat melaporkan kembali ke website kami http://www.simex.co.id pada bagian hubungi kami.

      Salam sejahtera,
      Product Department
      PT. Simex Pharmaceutical Indonesia

      Reply
  5. gerry

    Mau tanya konsumsi per hari klu kaadar sgot dn sgptny sktr 200an.brpa kaplet per hari? Makasih

    Reply
    • PT. Simex Pharmaceutical Indonesia

      Dear Bpk Gerry,

      Terimakasih atas kepercayaannya telah menggunakan Proliver.
      Mengenai dosis pemakaian, kami anjurkan sesuai dengan dosis rekomendasi yaitu 2-3 kaplet perhari.
      Apabila kadar Sgot dan Sgpt masih tinggi kami sarankan agar Bpk dapat berkonsultasi pada Dokter untuk mendapatkan solusi yang terbaik. Terimakasih

      Salam sehat,
      Product Department
      PT.Simex Pharmaceutical Indonesia

      Reply
  6. Asep Ramdhani

    Saya kesulitan dalam mendapatkan obat pro liver ini (khususnya hari minggu)
    Lokasi saya di bandung, biasanya saya membeli obat pro liver pada hari kerja
    Mohon untuk menjadi masukannya supaya bisa mensuplay ke apotik yang bisa buka 24 jam
    Terimakasih

    Reply
    • PT. Simex Pharmaceutical Indonesia

      Dear Bpk Asep Ramdhani,

      Terima kasih atas pertanyaan Bapak mengenai Proliver. Sebelumnya kami ingin menanyakan lokasi dimana Bapak Asep tinggal dan selanjutnya akan kami infokan melalui email pribadi Bapak mengenai lokasi terdekat untuk mendapatkan Proliver.

      Salam Sehat,
      Product Department
      PT. Simex Pharmaceutical Indonesia

      Reply
  7. Puji lestari

    Saya mencari obat ini sangat susah , setiap dtg ke apotik jawabannya tidak ada. Saya sdh cari di balikpapan sampai ke samarinda . Sekarang saya tinggal di samarinda daerah sempaja.

    Reply
    • PT. Simex Pharmaceutical Indonesia

      Dear Ibu Puji lestari,

      Ketersediaan produk PROLIVER dapat Ibu dapatkan di Apotek Sahabat (Depan RSUD A. Wahab Syahrani – Samarinda) dan Apotek Segiri (Depan Pasar Pusat Segiri – Samarinda).

      Salam Sehat,
      Product Department
      PT. Simex Pharmaceutical Indonesia

      Reply
  8. Puji lestari

    Saya mencari obat ini setiap dtg ke apotik jawabannya tidak ada. Saya sdh cari di balikpapan sampai ke samarinda . Sekarang saya tinggal di samarinda daerah sempaja.

    Reply
    • PT. Simex Pharmaceutical Indonesia

      Dear Ibu Puji lestari,

      Ketersediaan produk PROLIVER dapat Ibu dapatkan di Apotek Sahabat (Depan RSUD A. Wahab Syahrani – Samarinda) dan Apotek Segiri (Depan Pasar Pusat Segiri – Samarinda).

      Salam Sehat,
      Product Department
      PT. Simex Pharmaceutical Indonesia

      Reply

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