OSTEOARTHRITIS & THE PROBLEMS
Osteoarthritis, is one of articular disorders that involves damage to structures in joints. Osteoarthritis is due to degenerative process that results from metabolic, mechanical, genetic and other influences. Nowadays, osteoarthritis becomes the most common form of arthritis and is a leading cause of physical disability, increased health care usage, and impaired quality of life. The large, weight-bearing joints tend to be most adversely effected – in particular, the spine, hip, and knee. Symptoms include pain, stiffness, and reduced range of motion. Currently available medical therapies primarily address the treatment of joint pain in patients with osteoarthritis. Analgesics, especially Non Steroid Analgesics and anti Inflammatory Drugs (NSAID) are commonly used to treat osteoarthritis. With increasing issues regarding safety of NSAID to gastrointestinal system, there is a urgent need of pharmacological therapies proven to be effective and relatively safe in treatment of osteoarthritis.
GLUCOSAMINE & CHONDROITIN FOR OSTEOARTHRITIS
Glucosamine is amino monosaccharide and a basic building block for the biosynthesis of the glycosaminoglycans (GAG) and proteoglycans that are important constituents of the articular cartilage. Chondroitin (mainly in chondroitin sulphate form) is one of the six major GAGs and becoming part of chondrin matrix, which responsible in forming articular cartilage. Both glucosamine and chondroitin have been studied in osteoarthritis patients and the results show that combination glucosamine and chondroitin perform anti arthritic and anti-inflammatory activities.
One of large scale study performed in Glucosamine / chondroitin Arthritis Intervention Trial (GAIT) involving more than 1500 patients with osteoarthritis indicates that therapy using glucosamine / chondroitin combination (1500 mg glucosamine and 1200 mg chondroitin) were significantly more effective at reducing moderate to severe knee pain than placebo. Other study using combination glucosamine, chondroitin and methyl sulfonyl methane (MSM) is also performed to evaluate effectiveness this combination in treating osteoarthritis. As the result, combination using glucosamine, chondroitin and MSM was useful in decreasing pain, improving functional ability, and improving joint mobility and as well tolerated in patients with osteoarthritis.
RISING CONCERN OF SAFETY PROFILE
Regardless of the effectiveness of glucosamine / chondroitin therapy, there is a rising concern that glucosamine therapy may worsen blood glucose level, especially in people with impaired blood glucose regulation. There has been speculation that due to its chemical resemblance to glucose, high intakes of glucosamine might raise blood sugar. The mechanism by which glucosamine is hypothesized to affect blood glucose involves the roles of glucosamine and the hexosamine biosynthesis pathway in the regulation of glucose transport.
A double-blind placebo-controlled randomized controlled trial (RCT) involving more than 100 patients receiving combination of 1500 mg glucosamine and 1200 mg chondroitin sulphate daily demonstrated that oral glucosamine and chondroitin supplementation does not result in clinically significant alterations in glucose metabolism, even in patients with type 2 diabetes mellitus. This result is based on mean hemoglobin A1c (HbA1c) concentrations were not significantly different between pre treatment and post treatment and between control groups and diabetic groups. Other reviews also indicate that glucosamine does not have a diabetogenic effect.
Based on current research, glucosamine and chondroitin supplementation as supporting therapy for osteoarthritis seems to be safe and effective in reducing pain, preventing further degeneration and improving joint mobility. In safety profile, glucosamine and chondroitin do not alter glucose profile as long as consumed in recommended dosage. The most commonly suggested doses are 1500 mg for glucosamine and 1200 mg for chondroitin sulfate daily. These amounts are equally effective taken all at once or divided into two or three doses per day.
GCM & GCM FORTE
Good Life GCM and Good Life GCM Forte are excellent products from PT Simex Pharmaceutical Indonesia that contains glucosamine, chondroitin sulphate and methyl sulfonyl methane (MSM) with proper composition as mentioned in current research. Specifically for Good Life GCM Forte, the composition has 1500 mg glucosamine, 1200 chondroitin, and complemented with 500 mg of methyl sulfonyl methane (MSM) as safe analgesics and anti-inflammatory molecules. The preparation of Good Life GCM Forte is powder in sachet with ginger flavor that rapidly soothes pain and gives warm sensation. Good Life GCM Forte is also practical in dose (single dose therapy). With powerful combination and practical dose, Good Life GCM Forte is an exact and wise therapy in maintaining joint health and supporting therapy of osteoarthritis.
- Vidyasagar, Sudha.et al. Efficacy and Tolerability of Glucosamine Chondroitin Sulphate – Methyl Sulfonyl Methane (MSM) in Osteoarthritis of Knee in Indian Patients. Iranian Journal of Pharmacology & Therapeutics. July 2004. Vol 3 : No.2 (61-65)
- Clegg, D.O. et al. Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis. New England Journal of Medicine. February 2006. Vol 354 : No.8 (795-808)
- Shao, Andrew. Glucosamine, Chondroitin and Joint Health. Council for Responsible Nutrition. CRN Backgrounder.
- Marshall, D.P. et al. Do glucosamine and chondroitin worsen blood sugar control in diabetes?. The Journal of Family Practice. December 2006. VoL 55: No 12.